Water → 2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-6-methoxy-4-(piperidin-1-yl)pyridine-3,5-dicarbonitrile

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Reaction Steps

100.0 mg (0.21 mmol) of the compound from Example 4A are initially charged in 2 ml of dry methanol. 12.2 mg (0.23 mmol) of sodium methoxide are added to this solution, and the mixture is stirred at +65° C. for 20 h. After cooling to RT the reaction mixture is stirred into 2 ml of water and stirred at RT for 1 h. The precipitate that is formed is filtered off with suction and washed with 1 ml of cold water. Purification is carried out by preparative HPLC (column: YMC GEL ODS-AQ S-5, 15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).

Provenance & Evidence