Dichloromethane → Oxycodone Hydrochloride

Participants

Reaction Steps

To a 250 mL hydrogenation bottle was charged 1.5 g (4.75 mmol, prepared via Rh catalyst rearrangement, 424 ppm 14-hydroxycodeinone) of oxycodone base, 6 mL of dichloromethane (DCM) and 2 mL of isopropanol (IPA). The mixture was agitated until a solution was obtained, then 0.15 g of 10% Pd/C was added. The mixture was hydrogenated with agitation at 35° C., 25 psi H2 and processed to isolated oxycodone HCl in portions after one and two days of hydrogenation.

Provenance & Evidence