Morpholine → HCID 53241748, compound

Participants

Reaction Steps

126 mg (0.50 mmol) of 2-chloro-5-(4-fluorophenyl)-4H-pyrrolo[2,3-d]thiazole are suspended in 2 ml of morpholine in a microwave vessel and irradiated at 130° C. for 2 h and subsequently purified directly by chromatography on silica gel (eluent: cyclohexane/ethyl acetate 1/1), giving 139 mg (0.45 mmol, 91%) of 5-(4-fluorophenyl)-2-morpholin-4-yl-4H-pyrrolo[2,3-d]thiazole as beige crystals; m.p. 240-248;

Provenance & Evidence