2,4,6-Trimethylaniline → HCID 24881570, compound

Participants

Reaction Conditions

Reaction Steps

Acetic acid (0.086 mL, 1.5 mmol) was added to a round bottom flask charged with 2,6-difluoroaniline (3 mL, 30 mmol) and triethyl orthoformate (5 mL, 30 mmol). A vigreux column was attached and the solution was heated with stirring to 120° C. for 2 hours. 2,4,6-trimethylaniline (4.22 mL, 30 mmol) was then added to the reaction mixture. The solution was heated to reflux for an additional 2 hours and cooled to room temperature, whereupon crude product precipitated. Trituration with cold hexanes and vacuum filtration provided pure N-(2,6-difluorophenyl)-N′(mesityl)-formamidine (5.35 g, 65%) as a colorless powder.

Provenance & Evidence