Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Heptane | HCID 8900 | — |
| Reactant | Hexahydrofuro[2,3-b]furan-3-yl hydrogen {4-[(4-aminobenzene-1-sulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbonimidate--ethanol (1/1) | HCID 23725083 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Darunavir | HCID 213039 | 86.7% |
Reaction Steps
Darunavir Ethanolate (10 g) was dissolved in ethyl acetate (50 mL). The solution was heated to 40-45° C. and maintained for 30 min. Ethyl acetate was distilled off under vacuum completely to get residue in the form of semisolid. n-Heptane (50 mL) was added to the residue and stirred for 30 min. at ambient temperature. The separated solid was filtered, washed the wet cake with n-heptane (5 mL) and dried at 40-45° C. under vacuum to get 8.0 g of amorphous Darunavir.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08703980B2 |
|---|
| Source dataset | uspto-grants-2014_04 |
|---|
| ORD ID | ord-b5081a73071c4491891046f46c9a270d |
|---|
| Source note | uspto-grants-2014_04 |
|---|
