Dimethyl 5-aminoisophthalate → HCID 67174306, compound

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Reaction Steps

Dimethyl 5-aminoisophthalate (Aldrich, 0.441 g, 2.12 mmol) is dissolved in dry N,N-dimethylformamide (8 mL) in a 50 mL round bottom flask under an inert atmosphere. A 2.12 M solution of octadecylisocyanate (2.12 mmol) in dry N,N-dimethylformamide (1 mL) is then added dropwise. The residual octadecylisocyanate solution is quantitatively transferred with 2 portions of N,N′-dimethylformamide (1 mL each) and the reaction is stirred overnight at room temperature. The reaction is then heated to 100° C. for 22 h, and then cooled to room temperature to give a white slurry. The solid is then vacuum filtered, washed with fresh N,N-dimethylformamide followed by deionized water. The filtrate is then concentrated by rotary evaporation to give a white solid.

Provenance & Evidence