化工社化工社 化学情報印刷レポート · 研究参考用
Di-tert-butyl dicarbonate → Fluorene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Di-tert-butyl dicarbonate | HCID 90495 | — |
| 反応物 | 2-((Methylamino)methyl)fluorene | HCID 12689751 | — |
| 生成物 | Fluorene | HCID 6853 | — |
反応手順
A solution of fluorene-2-carbonyl chloride (prepared from fluorene-2-carboxylic acid and oxalyl chloride) in THF is added to aqueous methylamine (2 molar equivalents) to prepare N-methyl fluorene-2-carboxamide. Reduction of the amide using LiAlH4 in ether provides 2-((methylamino)methyl)fluorene. The amine is protected by reaction with di-tert-butyl dicarbonate to provide 24N-tBOC—N-methylamino)methyl)fluorene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08703907B2 |
| 出典データセット | uspto-grants-2014_04 |
| ORD ID | ord-efd9463f124d49fa8ff9c5cccd6483d0 |
| 出典メモ | uspto-grants-2014_04 |