HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (Z)-(S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-(3-methoxy-phenyl)-N,N,2-trimethyl pentylamine | HCID 22377020 | — |
| Product | (Z)-(S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine | HCID 11425684 | — |
Reaction Steps
The yield of [3-(3-methoxy-phenyl)-2-methyl-pentyl]-dimethyl-amine; hydrochloride (3) was >96% with a ratio of the enantiomer (−)-(2R,3R) to the diastereoisomer (−)-(2R,3S) of 76:24. The (−)-(2R,3R) enantiomer is preferably used as an active ingredient in medicaments.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08704002B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-9e75a225b2f543568d569e62b20eeb79 |
| Source note | uspto-grants-2014_04 |