HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dihydroxy-2-naphthoic acid → Methyl 1,4-dihydroxy-2-naphthoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dihydroxy-2-naphthoic acid | HCID 671 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 1,4-dihydroxy-2-naphthoate | HCID 604167 | 82.3% |
Reaction Steps
1,4-Dihydroxy-2-naphthoic acid (10 g, 49 mmol) and NaHCO3 (4.12 g, 49 mmol) was dissolved in DMF (dimethylformamide) (50 mL). Methyl iodide (6.96 g, 49 mmol) was added and the solution stirred at room temperature for 24 h, poured into water (1 L), filtered and washed with water to give the title compound (8.80 g, 82%) as a green powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703978B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-85f82f36358b4ecb9d2d94ba7a6cc5e8 |
| Source note | uspto-grants-2014_04 |