HCID 20304552, compound → HCID 20304538, compound

Participants

Reaction Steps

A solution of the product of Example 23 (1.4 g) in ethanol (25 ml) was treated with a 5% palladium on charcoal catalyst (50 mg) and hydrogenated at 45 psi/room temperature for 5 hours. Catalyst was filtered off and the ethanolic filtrate was evaporated to low bulk, treated with sodium bicarbonate (0.8 g) and water (30 ml), and heated under reflux for 1 hour. The solution was evaporated, diluted with water and filtered and the filtrate was acidified. The precipitated acid was filtered off, washed with water, dried and the title compound recovered as a pale yellow powder (1.4 g), mp 208° (decomp).

Provenance & Evidence