Toluene → 1-Naphthol

Participants

Reaction Conditions

Reaction Steps

The compound of the above formula (38) was dissolved in 120 ml of toluene and heated to 90° C. 57.6 g (303.0 mmol) of p-toluenesulfonic acid monohydrate was added to this solution and refluxed for 4 hours. After a reaction, the reaction product was washed with water, the solvent was removed, and the obtained product was purified by column chromatography to obtain a naphthol compound represented by the following formula (39) as 4.4 g (7.1 mmol, yield of 76%) of a white solid.

Provenance & Evidence