Ethylene Glycol → HCID 57429413, compound

Participants

Reaction Steps

Ethylene glycol (18 mL, 0.32 mol, 1.2 eq), paratoluene sulfonic acid (400 mg, 1% w/w) and cyclohexane (50 mL) were charged into a 1 L three-necked round-bottom flask, equipped with a dean and stark, a reflux condenser and a mechanical stirrer. Florhydral™ 3-(3-isopropylphenyl)butanal, 49.3 g, 0.26 mol) was added dropwise at ambient temperature. The stirred mixture was then heated for 3 h at reflux. The reaction mixture was cooled at ambient temperature and washed water (2×100 mL), dried over magnesium sulphate and concentrated. The resulting crude product was distilled with a Vigreux column (7.2 mBar, 146° C.), to give 2-[2-(3-isopropylphenyl)propyl]-1,3-dioxolane (239 g, gc purity>98%; yield 97%).

Provenance & Evidence