Triethylamine → HCID 86647138, compound

Participants

Reaction Steps

1-Boc-amino-2-methylamino-ethane (1 g, 4.75 mmol) and tert-butyl acrylate (0.61 g, 4.75 mmol) were dissolved in ethanol (10 mL) with triethylamine (1.32 mL, 9.5 mmol) and refluxed overnight. The solvent was evaporated in vacuo, and 3-(Boc-aminoethyl-methyl-amino)-propionic acid tert-butyl ester was isolated by addition of ethyl acetate (300 ml) and washing with 2×5% sodium carbonate, water and brine followed by drying over magnesium sulphate and evaporation in vacuo to leave an oil (630 mg, 44%).

Provenance & Evidence