反应详情

温度

140 °C

2-Aminoisophthalic acid (50.0 g; 276.0 mmol) and Ac2O (250.0 ml; 5.00 V) were combined and heated to 140° C. for 4 h. The reaction mixture was cooled to room temperature and distilled under high vacuum on the rotary evaporator. The remaining AcOH was removed by azeotropic distillation with toluene. The residue was slurried with ethyl ether, filtered, and the solid was dried under vacuum to provide the desired intermediate (50.3 g, 89% yield).

1. temperatureThe reaction mixture was cooled to room temperature
2. distillationdistilled under high vacuum on the rotary evaporator
3. customThe remaining AcOH was removed by azeotropic distillation with toluene
4. filtrationfiltered
5. customthe solid was dried under vacuum