Ammonia → HCID 66714522, compound

HRID 2369815Notes

Reaction equation

HRID 2369815 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([NH:24][C:25]2[C:34]3[C:29](=[C:30]([C:35]([O:37]C)=O)[CH:31]=[CH:32][CH:33]=3)[N:28]=[C:27]([CH3:39])[N:26]=2)[CH2:9][N:10]([CH3:23])[S:11]([C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[CH:4][CH:3]=1.[NH3:40]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([NH:24][C:25]2[C:34]3[C:29](=[C:30]([C:35]([NH2:40])=[O:37])[CH:31]=[CH:32][CH:33]=3)[N:28]=[C:27]([CH3:39])[N:26]=2)[CH2:9][N:10]([CH3:23])[S:11]([C:14]2[CH:15]=[CH:16][C:17]([N+:20]([O-:22])=[O:21])=[CH:18][CH:19]=2)(=[O:12])=[O:13])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 66714837HCID 66714837, compound

Product 1

HCID 66714522HCID 66714522, compound

Conditions

Temperature
70 °C

Procedure

Crude methyl 4-[((1S)-1-(4-fluorophenyl)-2-{methyl[(4-nitrophenyl)sulfonyl]-amino}ethyl)amino]-2-methylquinazoline-8-carboxylate (177 mg; 0.32 mmol) was treated with methanolic ammonia (10 ml, 7M), and stirred at 70° C. overnight. The reaction mixture was concentrated to provide the desired crude intermediate. (M+H) 539.1

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-6526a5e818064d319f3a1f0cadd051d7
Source dataset
uspto-grants-2014_04
Patent number
US08710044B2

Reaction notes

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