Dimethylformamide → HCID 178507511, compound

Participants

Reaction Steps

1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (EDCI, 0.377 g, 1.97 mmol) was added to a solution of 1,2-diaminobenzene (0.141 g, 1.31 mmol), 5-[2[(4-hydroxyphenyl)-vinyl]-2H-pyrazol-3-carboxylic acid (0.301 g, 1.31 mmol) and HOBt (0.266 g, 1.97 mmol) in anhydrous DMF (7 mL). The reaction was stirred under nitrogen at room temperature. After twelve hours the reaction was concentrated in vacuo and precipitated from methanol with a small amount of water. The solid was collected by vacuum filtration and further purified on reverse phase HPLC using water-acetonitrile gradient (0.1% TFA) to provide the corresponding amide (44 mg, 10% yield).

Provenance & Evidence