6alpha,9-Difluoro-11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate → HCID 58187768, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of intermediate 2 (2.55 g, 6.06 mmol) in ethanol (100 ml), Candida antarctica Lipase (2 U/mg) (510 mg, 6.06 mmol) was added, and the reaction mixture was stirred at 37° C. overnight. The reaction mixture was filtered, washing with methanol, and the residue was purified by flash chromatography on silica gel, in gradient elution from DCM/AcOEt 90:10 to DCM/AcOEt 50:50, to afford the title compound (1.62 g, 70.6% yield).

Provenance & Evidence