HCID 71245530, compound → HCID 71245548, compound

Participants

Reaction Conditions

Reaction Steps

A solution of compound 16 (171 mg, 0.290 mmol) in MeOH (4 ml) was degassed bubbling nitrogen at RT for 20 minutes. After cooling to 0° C. K2CO3 (12 mg, 0.0.87 mmol) was added, and the mixture was stirred for 1 hour. The mixture was partitioned between AcOEt and brine. The organic phase was separated, dried over Na2SO4 and concentrated. The crude was purified by preparative HPLC(CH3CN/H2O without CF3COOH) to give the title compound (45 mg, 28% yield).

Provenance & Evidence