Bromine → 3-Bromo-6-chloroimidazo(1,2-b)pyridazine

HRID 2370040Notes

Reaction equation

HRID 2370040 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.[Br:11]Br>C(O)(=O)C>[Br:11][C:8]1[N:6]2[N:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]2=[N:10][CH:9]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 138828Imidazo(1,2-b)pyridazine, 6-chloro-

Product 1

HCID 128723233-Bromo-6-chloroimidazo(1,2-b)pyridazineYield 60%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The 6-Chloro-imidazo[1,2-b]pyridazine (4) (500 mg, 0.0032 mol) was taken in glacial acetic acid (5 ml) and bromine (0.4 ml) was added slowly at room temperature. After 20 minutes, solid precipitated out and was filtered. The solid was washed with ether (3×15 ml) and dried under air to give 3-Bromo-6-chloro-imidazo[1,2-b]pyridazine (5) (400 mg, yield=60%).

Workup

  1. customsolid precipitated out and
  2. filtrationwas filtered
  3. washThe solid was washed with ether (3×15 ml)
  4. customdried under air

Sources & evidence

ORD record
ord-5f407c7773ab4ce8b5f0d14561fe2437
Source dataset
uspto-grants-2014_04
Patent number
US08710057B2

Reaction notes

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