反应详情

6-chloro-5-methylpyridazin-3-amine 7 (0.6 g, 4.18 mmol) was dissolved in n-butanol (10 ml) and chloroacetaldehyde (0.328 g, 4.18 mmol) was added. The reaction was refluxed for 6 hrs and n-butanol was removed under reduced pressure. The crude product was purified by column chromatography (DCM/hexane, 70:30) to afford compound 8 (0.234 g, yield=33.4%).

1. temperatureThe reaction was refluxed for 6 hrs
2. customn-butanol was removed under reduced pressure
3. customThe crude product was purified by column chromatography (DCM/hexane, 70:30)