Bromine → 3-Bromo-6-chloro-7-methylimidazo[1,2-b]pyridazine

HRID 2370045Notes

Reaction equation

HRID 2370045 reaction equation
[Cl:1][C:2]1[C:3]([CH3:11])=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.[Br:12]Br>C(O)(=O)C>[Br:12][C:8]1[N:6]2[N:7]=[C:2]([Cl:1])[C:3]([CH3:11])=[CH:4][C:5]2=[N:10][CH:9]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 122483366-Chloro-7-methylimidazo[1,2-b]pyridazine

Product 1

HCID 593802983-Bromo-6-chloro-7-methylimidazo[1,2-b]pyridazineYield 69.8%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The 6-chloro-7-methylimidazo[1,2-b]pyridazine 8 (0.230 g, 1.372 mmol) was taken in glacial acetic acid (10 ml) and bromine (0.070 ml, 1.372 mmol) was added slowly at room temperature. After 20 mins the solvents were evaporated the obtained brown solid was washed with ether (3×15 ml) and dried under air to furnish compound 9 (0.236 g, yield 69.8%).

Workup

  1. customAfter 20 mins the solvents were evaporated the obtained brown solid
  2. washwas washed with ether (3×15 ml)
  3. customdried under air

Sources & evidence

ORD record
ord-040716b265824e1a9303800813062936
Source dataset
uspto-grants-2014_04
Patent number
US08710057B2

Reaction notes

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