Benzaldehyde → HCID 69132355, compound

Participants

Reaction Conditions

Reaction Steps

Compound A (3.51 g) was added to a 40 mL of dimethylformamide solution containing benzaldehyde (1 eq.) and 4 equivalents of triethylamine (4 eq.). The solution was refluxed at 60° C. for 16 hr and cooled at an ice bath to produce a yellow precipitate. The precipitate was then collected and washed with ethyl acetate to give 3.3 g (83%) of 3-[(5-benzyloxypyridin-2-yl)methylidene]-6-(benzylmethylidene)piperazine-2,5-dione (Compound B). mp: 223-225° C.; 1H-NMR (400 MHz, DMSO): 5.243 (s, 2H), 6.695 (s, 1H), 6.812 (s, 1H), 7.346-7.634 (m, 12H, aromatic), 8.528 (s, 1H), 10.245 (s, 1H), and 12.289 (s, 1H).

Provenance & Evidence