Water → HCID 69132345, compound

Participants

Reaction Steps

Compound B (0.5 g) and NaOH (0.5 g) were dissolved in 100 mL of methanol. The mixture was hydrogenated in the presence of 0.5 g of palladium/charcoal under 1 atmospheric pressure. After the completion of the reaction as monitored by TLC, the catalyst was removed by filtration and the filtrate was evaporated in vacuo to produce a residue, which was dissolved with 50 mL of water. The obtained aqueous solution was adjusted to PH=7. A precipitate was formed and collected to give a 0.27 g (70%) of 3-[(5-hydroxypyrid-in-2-yl)methylidene]-6-(benzylmethylidene)piperazine-2,5-dione (Compound C). 1H-NMR (400 MHz, CDCl3): 6.758 (s, 1H), 7.087 (s, 1H), 7.290-7.580 (m, 7H, aromatic), 8.328 (s, 1H), and 12.289 (s, 1H).

Provenance & Evidence