Sodium Carbonate → HCID 70662762, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of Compound C (1 g), 4-(bromomethyl)pyridine (2 g), sodium carbonate (2 g), and DMF (50 mL) were stirred at 100° C. for 16 hr and cooled at an ice bath to produce a yellow precipitate. The precipitate was then collected and washed with water to give 0.38 g (30%) of 3-benzylidene-6-((5-(pyridin-4-ylmethoxy)pyridin-2-yl)methylene)piperazine-2,5-dione (Compound 1). mp 254-255° C.; 1H-NMR (400 MHz, CDCl3), 5.26 (s, 2H) 6.78 (s, 1H), 7.11 (s, 1H), 7.31-7.59 (m, 9H), 8.20 (s, 1H), 8.48 (dd, J=2.8 Hz, 1H),), 8.72, (s, 2H), 12.50 (s, 1H).

Provenance & Evidence