2-(((Tert-butoxy)carbonyl)amino)-2-phenylacetic acid → HCID 60197432, compound

Participants

Reaction Steps

2-(Tert-butoxycarbonylamino)-2-phenylacetic acid was dissolved in DMF and treated with HBTU. Compound C were then added into the mixture and stirred. After the completion of reaction, the reaction mixture was partitioned by K2CO3(aq) and CH2Cl2. The organic layer was collected, dried over MgSO4(s), and dried by rotary evaporator. The solid residues were then purified by column chromatography to get Compound 8. mp 198° C.; 1H-NMR (400 MHz, CDCl3): δ 1.50 (s, 9H), 5.48 (s, 1H), 5.58-5.59 (m, 1H), 6.78 (s, 1H), 7.11 (s, 1H), 7.37-7.50 (m, 13H), 8.22 (s, 1H), 8.42 (s, 1H), 12.46 (s, 1H).

Provenance & Evidence