Trifluoroacetic acid → HCID 86670629, compound

Participants

Reaction Conditions

Reaction Steps

Compound 8 (0.126 g) was dissolved in 10 mL of dichloromethane and then 2.5 mL of trifluoroacetic acid was added slowly at 0° C. The reaction mixture was stirred at 0° C. and monitored by TLC until the starting material disappeared. It was concentrated by rotary evaporator to a give a crude compound, which was recrystallized in acetonitrile to give Compound 9 as a yellow solid (71%). mp 280° C.; 1H-NMR (400 MHz, DMSO): δ 5.69 (s, 1H), 6.79 (s, 1H), 6.86 (s, 1H), 7.34-7.38 (m, 1H), 7.44 (dd, J=7.6 Hz, 7.6 Hz, 2H), 7.55-7.58 (m, 5H), 7.65-7.67 (m, 2H), 7.71-7.74 (m, 1H), 7.80-7.82 (m, 1H), 8.59 (s, 1H), 8.91 (br, 3H), 10.42 (br, 1H), 12.16 (s, 1H).

Provenance & Evidence