p-Toluenesulfonic acid → HCID 86675238, compound

Participants

Reaction Steps

Heat a mixture of 2-[(5-amino-6-chloro-2-methyl-pyrimidin-4-yl)amino]acetamide (2.2 g, 0.01 mol), 2-chlorobenzaldehyde (2.86 g, 0.02 mol), p-toluene sulfonic acid (0.2 g) and molecular sieves (1.0 g) in toluene (50 mL) to reflux for 16 h. Cool and remove the sieves by filtration through diatomaceous earth. Concentrate the filtrate under reduced pressure to afford a residue. Dissolve the residue in dry dichloromethane (50 mL) and add 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (2.3 g, 0.01 mol) at 0° C. Allow to warm to room temperature and stir for 2 h. Dilute the reaction mixture with dichloromethane, wash with 1 N aqueous sodium hydroxide solution, water, and brine. Dry the organic layer over anhydrous sodium sulfate, filter, and concentrate to give a residue. Purify the residue on a silica gel column eluting with dichloromethane:methanol (98:2) to provide the title compound (0.3 g). ES/MS m/z 336 (M+1).

Provenance & Evidence