Trifluoroacetic acid → HCID 67446836, compound

Participants

Reaction Steps

Add trifluoroacetic acid (3 mL) to a solution of tert-butyl N-[2-[8-(2-chlorophenyl)-6-(4-ethylpiperazin-1-yl)-2-methyl-purin-9-yl]ethyl]carbamate (0.6 g, 1.2 mmol) in dichloromethane (3 mL) at 0° C. and stir for 2 h at room temperature. Quench the reaction mixture with saturated aqueous sodium bicarbonate solution, and extract with dichloromethane. Dry the organic layer over anhydrous sodium sulfate, filter, and concentrate to give a residue. Purify the residue on a silica gel column using dichloromethane-methanol (96:4) as eluent to give 2-[8-(2-chlorophenyl)-6-(4-ethylpiperazin-1-yl)-2-methyl-purin-9-yl]ethanamine (0.3 g). ES/MS m/z 400 (M+1).

Provenance & Evidence