HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Naphthaldehyde → 6-(Morpholino)-2-(naphthalen-1-yl)quinazolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Naphthaldehyde | HCID 6195 | — |
| Reactant | 2-Amino-5-(morpholin-4-yl)benzamide | HCID 10560936 | — |
| Product | 6-(Morpholino)-2-(naphthalen-1-yl)quinazolin-4-one | HCID 136272158 | — |
Reaction Steps
Compound 29 was synthesized from 5-morpholinyl-2-aminobenzamide (13) (1.6 g, 7.3 mmol) and 1-naphthaldehyde (14) (1.1 g, 7.3 mmol): yield 1.7 g (64%); yellow crystals; mp 291 to 293° C.; 1H NMR (DMSO-d6) δ 3.22 (4H, t, J=4.7 Hz, CH2NCH2), 3.77 (4H, t, J=4.7 Hz, CH2OCH2), 7.51-7.66 (6H, m, 6×ArH), 7.73-7.76 (1H, m, 1×ArH), 8.00-8.11 (3H, m, 3×ArH), 12.48 (1H, br s, NH) ppm; MS (ESI) m/z 357; Anal. (C22H19N3O2): C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08710064B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-a6e763cbf90644f39f7822148a155583 |
| Source note | uspto-grants-2014_04 |