HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzothiophene-3-carbaldehyde → 6-(Morpholino)-2-(benzo[b]thiophen-3-yl)quinazolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzothiophene-3-carbaldehyde | HCID 227328 | — |
| Reactant | 2-Amino-5-(morpholin-4-yl)benzamide | HCID 10560936 | — |
| Product | 6-(Morpholino)-2-(benzo[b]thiophen-3-yl)quinazolin-4-one | HCID 136272170 | — |
Reaction Steps
Compound 31 was synthesized from 5-morpholinyl-2-aminobenzamide (13) (1.6 g, 7.3 mmol) and thianaphthene-3-carboxaldehyde (16) (1.2 g, 7.3 mmol): yield 1.6 g (60%); brown crystals; mp>300° C.; 1H NMR (DMSO-d6) δ 2.47 (4H, t, J=4.7 Hz, CH2NCH2), 3.75 (4H, t, J=4.7 Hz, CH2OCH2), 7.44-7.59 (4H, m, 4×ArH), 7.67-7.72 (1H, m, 1×ArH), 8.03-8.07 (1H, m, 1×ArH), 8.67 (1H, s, 1×ArH), 8.96-9.00 (1H, m, 1×ArH), 12.31 (1H, br s, NH) ppm; MS (ESI) m/z 363; Anal. (C20H17N3O2S): C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08710064B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-1b57f897a03643e1bf2d63d1dcf19079 |
| Source note | uspto-grants-2014_04 |