Methylamine hydrochloride → HCID 58075784, compound

Participants

Reaction Steps

2,4-dichloro-8-(4-chlorophenyl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine (Preparation K) (500 mg, 1.584 mmol) and methanamine hydrochloride (160 mg, 2.377 mmol) were combined and purified as per Preparation Ha to give 2-chloro-8-(4-chlorophenyl)-N-methyl-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-amine (150 mg, 0.484 mmol, 30.5% yield). LC-MS (M+H)+=310.0. 1H NMR (500 MHz, CDCl3) δ ppm 7.22-7.31 (2 H, m), 7.13 (2 H, d, J=8.55 Hz), 4.46-4.64 (1 H, m), 4.43 (1 H, br. s.), 3.97-4.14 (1 H, m), 3.91 (1 H, d, J=3.36 Hz), 3.09 (3 H, d, J=4.88 Hz).

Provenance & Evidence