Methylamine hydrochloride → HCID 58075445, compound

Participants

Reaction Steps

8-(4-bromophenyl)-2,4-dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine (Preparation L) (500 mg, 1.389 mmol) and methanamine hydrochloride (141 mg, 2.083 mmol) were combined and purified as per Preparation Ha to give 8-(4-bromophenyl)-2-chloro-N-methyl-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-amine (210 mg, 0.592 mmol, 42.6% yield). LC-MS (M+H)+=356.0. 1H NMR (500 MHz, MeOD) δ ppm 7.46 (2 H, d, J=8.24 Hz), 7.13 (2 H, d, J=8.55 Hz), 4.43-4.71 (2 H, m), 4.09 (1 H, dd, J=11.44, 4.12 Hz), 3.92-4.03 (1 H, m), 3.86 (1 H, d, J=3.05 Hz), 3.00 (3 H, s).

Provenance & Evidence