Dimethylamine → HCID 58075793, compound

HRID 2370211Notes

Reaction equation

HRID 2370211 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[CH2:8][CH2:7][CH2:6][CH:5]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[C:4]=2[N:3]=1.[CH3:20][NH:21][CH3:22]>CO>[Cl:1][C:2]1[N:11]=[C:10]([N:21]([CH3:22])[CH3:20])[C:9]2[CH2:8][CH2:7][CH2:6][CH:5]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[C:4]=2[N:3]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 58075728HCID 58075728, compound

Product 1

HCID 58075793HCID 58075793, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2,4-dichloro-8-(4-fluorophenyl)-5,6,7,8-tetrahydroquinazoline (115 mg, 0.387 mmol) and excess dimethylamine (1.935 mL, 3.87 mmol) in MeOH (1 mL) was stirred at room temperature for 1 h. The solvent was removed in vacuum to afford 2-chloro-8-(4-fluorophenyl)-N,N-dimethyl-5,6,7,8-tetrahydroquinazolin-4-amine (118 mg, 0.386 mmol, 100% yield). LC-MS (M+H)+=306.2.

Workup

  1. customThe solvent was removed in vacuum

Sources & evidence

ORD record
ord-d228bdde499446e5bdcf6dd4b084399a
Source dataset
uspto-grants-2014_04
Patent number
US08710061B2

Reaction notes

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