HCID 766883, compound → 4-[[4-(2-Pyridinyl)-1-piperazinyl]sulfonyl]benzenamine

Participants

Reaction Steps

A mixture of 10.62 g (0.0305 m) of 1-[(p-nitrophenyl)sulfonyl]-4-(2-pyridinyl)piperazine, 1.5 g of 5% palladium on charcoal, and 150 ml of absolute ethanol is shaken under hydrogen on a Parr hydrogenator. After the theoretical amount of hydrogen has been taken up, the catalyst is filtered off and the filtrate is taken to dryness. The product, 1-[(p-aminophenyl)sulfonyl]-4-(2-pyridinyl)piperazine, is crystallized from methanol/methylene chloride to give 7.89 g (81%) of 1-[(p-aminophenyl)sulfonyl]-4-(2-pyridinyl)piperazine of melting point 208°-210° C.

Provenance & Evidence