HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 1-(3-Chlorophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 1-(3-Chlorophenyl)-4-(4-nitrophenyl)sulfonylpiperazine | HCID 1019725 | — |
| Catalyst | titanium(III) trichloride | HCID 10313229 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(3-Chlorophenyl)piperazine | HCID 1355 | — |
Reaction Steps
1-[(p-Nitrophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine is reduced with aqueous titanium trichloride in ether solution by dropwise addition of aqueous TiCl3 until the purple color is no longer discharged. The reaction progress is followed by thin layer chromatography. Work-up with concentrated ammonium hydroxide and subsequently aqueous potassium hydroxide followed by isolation, drying, and concentration of the organic layer gives 1-[p-aminophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04159331 |
| Source dataset | uspto-grants-1979_06 |
| ORD ID | ord-abb38bd69cbe41e4b74d1fd6d4d564b2 |
| Source note | uspto-grants-1979_06 |