Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | 6-[(Piperidin-4-yl)oxy]isoquinolin-1(2H)-one--hydrogen chloride (1/1) | HCID 42635918 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1417424-23-7 | HCID 86675574 | — |
Reaction Steps
10 g crude 6-(Piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride were dissolved in 25 mL water at 70 C. The solution was cooled to 55° C. and 75 mL acetone were added. The mixture was cooled to room temperature within 3 hours and left standing for two days for crystallization. After cooling (4° C.) for 6 hours the product was isolated via filtration, washed with acetone/water (3:1) and dried in vacuum. 7.9 g (purity 97.1%) of 6-(Piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride dihydrate were obtained. Water content (Karl Fischer): 10.52%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08710078B2 |
|---|
| Source dataset | uspto-grants-2014_04 |
|---|
| ORD ID | ord-09224a2d95eb478e920de3b60354b2c8 |
|---|
| Source note | uspto-grants-2014_04 |
|---|
