Tributylvinyltin → HCID 68089334, compound

Participants

Reaction Conditions

Reaction Steps

(3-Bromo-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)(4-fluorophenyl)methanone (150 mg, 0.4 mmol; prepared as described above), tributyl(vinyl)tin (185 mg, 0.6 mmol) and Pd(PPh3)4 (58 mg, 0.05 mmol) were combined in toluene (12 mL) and heated at 120° C. for 1 h. The reaction mixture was cooled to RT, filtered through celite, adsorbed onto silica gel, and eluted with CH2Cl2:MeOH (9:1) to give 104 mg (82%) of (4-fluorophenyl)(3-vinyl-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)methanone. LC-MS (M+H)=283.1.

Provenance & Evidence