4-Chloro-7-(trifluoromethyl)quinoline → HCID 21314801, compound

HRID 237026Notes

Reaction equation

HRID 237026 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([N:26]2[CH2:31][CH2:30][N:29]([C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([Cl:38])[CH:33]=3)[CH2:28][CH2:27]2)(=[O:25])=[O:24])=[CH:19][CH:18]=1>>[Cl:38][C:34]1[CH:33]=[C:32]([N:29]2[CH2:28][CH2:27][N:26]([S:23]([C:20]3[CH:21]=[CH:22][C:17]([NH:16][C:2]4[C:11]5[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=5)[N:5]=[CH:4][CH:3]=4)=[CH:18][CH:19]=3)(=[O:25])=[O:24])[CH2:31][CH2:30]2)[CH:37]=[CH:36][CH:35]=1

Participants

3

Reactant 2

HCID 676684-Chloro-7-(trifluoromethyl)quinolineHCID 21314895HCID 21314895, compound

Product 1

HCID 21314801HCID 21314801, compound

Procedure

In the matter given in Example 1C, 4-chloro-7-(trifluoromethyl)quinoline is heated with 1-[(p-aminophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine to give 1-(m-chlorophenyl)-4-[[4-[[7-(trifluoromethyl)4-quinolinyl]amino]phenyl]sulfonyl]piperazine.

Sources & evidence

ORD record
ord-201a18642aa54d789c2c65b152febd9c
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Reaction notes

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