Water → 6-fluoro-2-(4-methoxybenzyl)-7-methylisoquinolin-1(2H)-one

Participants

Reaction Steps

To a solution of 9.17 g of 6-fluoro-7-methyl-2H-isoquinolin-1-one (12) in 80 ml DMF were added 20.2 g caesium carbonate and then 8.92 g 4-methoxybenzyl-chloride. After stirring at room temperature for 90 minutes the reaction mixture was poured into 600 ml water, stirred for 1 h, and then the precipitated product was filtrated by suction. From the mother liquor additional producted was isolated by chromatography with heptane/ethyl acetate (80:20). The combined products were recrystallized from ethyl acetate and 8.39 g 6-fluoro-2-(4-methoxy-benzyl)-7-methyl-2H-isoquinolin-1-one (13) were received. Rt=1.83 min (Method B). Detected mass: 298.1 (M+H+).

Provenance & Evidence