4-Allyl-4-amino-cyclohexanol → 6-(4-Allyl-4-amino-cyclohexyloxy)-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one

Participants

Reaction Steps

422 mg of 6-(4-allyl-4-amino-cyclohexyloxy)-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (18) were synthesized as diastereomeric mixture starting from 641 mg (2.26 mmol) of 2-(4-methoxy-benzyl)-6-fluoro-2H-isoquinolin-1-one (9) and 370 mg (2.38 mmol) of 4-allyl-4-amino-cyclohexanol (16), following the protocol described for 6-(4-allyl-4-amino-cyclohexyloxy)-7-chloro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (17). Rt=1.07 min, 1.10 min (Method C). Detected mass: 419.2 (M+H+).

Provenance & Evidence