9-Borabicyclo(3.3.1)nonane → HCID 59226062, compound

Participants

Reaction Steps

1.14 g of [5-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-(3-hydroxy-propyl)-cyclooctyl]-carbamic acid tert-butyl ester (59) were synthesized using the procedure described for the synthesis of [4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-(3-hydroxy-propyl)-cyclohexyl]-carbamic acid tert-butyl ester (53) starting from 1.17 g (2.12 mmol) of [1-allyl-5-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-cyclooctyl]-carbamic acid tert-butyl ester (58) and 12.7 mL (6.37 mmol) of 9-BBN (0.5M solution in THF). Rt=1.71 min (Method I). Detected mass: 569.3 (M+H+).

Provenance & Evidence