Hydrochloric Acid → HCID 25151767, compound

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Reaction Steps

168 mg of 6-[5-amino-5-(3-hydroxy-propyl)-cyclooctyloxy]-7-chloro-2H-isoquinolin-1-one (60) were synthesized as diastereomeric mixture as hydrochloride from 300 mg (0.53 mmol) of [5-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-(3-hydroxy-propyl)-cyclooctyl]-carbamic acid tert-butyl ester (59) using the standard deprotection procedure described for the synthesis of 6-(cis-4-amino-4-cyclopropyl-cyclohexyloxy)-7-chloro-2H-isoquinolin-1-one (41). Rt=2.07 min, 2.12 min (Method H). Detected mass: 379.2 (M+H+).

Provenance & Evidence