HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → [1-(4-Fluoro-phenyl)-4-oxo-cyclohexyl]-carbamic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | [8-(4-Fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-carbamic acid benzyl ester | HCID 59226068 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | [1-(4-Fluoro-phenyl)-4-oxo-cyclohexyl]-carbamic acid benzyl ester | HCID 59226032 | — |
Reaction Steps
2.75 g of [8-(4-Fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-carbamic acid benzyl ester (76) were dissolved in 30 mL of acetone and 15 mL of 5N HCl. When conversion was complete, the mixture was carefully poured into sat. sodium bicarbonate solution. The aqueous layer was extracted twice with dichloromethane,
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08710077B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-216b874459db4ab0844e900a293af86e |
| Source note | uspto-grants-2014_04 |