反应详情

0.5 g of [1-(4-Fluoro-phenyl)-4-hydroxy-cyclohexyl]-carbamic acid benzyl ester (78) were dissolved in 50 mL of methanol and 57 mg of palladium on charcoal (10%) were added. The mixture was stirred under a hydrogen atmosphere until conversion was complete. The catalyst was filtered off and the organic layer was evaporated to dryness to give 290 mg of the desired product. Rt=0.73 min (Method E). Detected mass: 175.2 (M+H—H2O—NH3+).

1. filtrationThe catalyst was filtered off
2. customthe organic layer was evaporated to dryness