4-Chloro-7-(trifluoromethyl)quinoline → HCID 21314855, compound

HRID 237033Notes

Reaction equation

HRID 237033 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][CH2:20][C:21]([Cl:24])([Cl:23])[Cl:22])=[O:18])[CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl[C:26]1[C:35]2[C:30](=[CH:31][C:32]([C:36]([F:39])([F:38])[F:37])=[CH:33][CH:34]=2)[N:29]=[CH:28][CH:27]=1>>[F:39][C:36]([F:37])([F:38])[C:32]1[CH:31]=[C:30]2[C:35]([C:26]([NH:1][C:2]3[CH:7]=[CH:6][C:5]([S:8]([N:11]4[CH2:16][CH2:15][N:14]([C:17]([O:19][CH2:20][C:21]([Cl:24])([Cl:23])[Cl:22])=[O:18])[CH2:13][CH2:12]4)(=[O:10])=[O:9])=[CH:4][CH:3]=3)=[CH:27][CH:28]=[N:29]2)=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 676684-Chloro-7-(trifluoromethyl)quinolineHCID 21314833HCID 21314833, compound

Product 1

HCID 21314855HCID 21314855, compound

Procedure

In the manner given in Example 4C, 1-(p-aminophenylsulfonyl)-4-(2,2,2-trichloroethoxycarbonyl)piperazine is heated with 4-chloro-7-trifluoromethylquinoline to give 1-[[4-[(7-trifluoromethyl-4-quinolinyl)amino]phenyl]-sulfonyl]-4(2,2,2-trichloroethoxycarbonyl)piperazine.

Sources & evidence

ORD record
ord-6d16fdd154734382ac4ea72405a06fe3
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Reaction notes

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