Methyl iodide → HCID 66732832, compound

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared according to General Method 5. A solution of 2-(4-(tert-butylcarbamoyl)-3-fluorophenylamino)-2-methylpropanoic acid (1.0 g, 3.3 mmol) and K2CO3 (1.38 g, 10 mmol) in DMF (10 mL) was stirred at RT for 10 minutes. Methyl iodide (710 mg, 5 mmol) was added and heated at 55° C. for 4 h. The solvent was removed and reaction mixture was poured in water, extracted with ethyl acetate (100 mL, 2 times), dried over Na2SO4, concentrated and purified with column chromatography to obtain 300 mg of methyl 2-(4-(tert-butylcarbamoyl)-3-fluorophenylamino)-2-methylpropanoate

Provenance & Evidence