4-Chlorobenzenesulfonyl chloride → 1-[(4-Chlorophenyl)sulfonyl]-4-[[4-[[7-chloro-4-quinolinyl]amino]phenyl]sulfonyl]-piperazine

HRID 237035Notes

Reaction equation

HRID 237035 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17]([NH:23][C:24]3[CH:29]=[CH:28][C:27]([S:30]([N:33]4[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]4)(=[O:32])=[O:31])=[CH:26][CH:25]=3)=[CH:18][CH:19]=[N:20]2)=[CH:15][CH:14]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:36]2[CH2:37][CH2:38][N:33]([S:30]([C:27]3[CH:28]=[CH:29][C:24]([NH:23][C:17]4[C:16]5[C:21](=[CH:22][C:13]([Cl:12])=[CH:14][CH:15]=5)[N:20]=[CH:19][CH:18]=4)=[CH:25][CH:26]=3)(=[O:31])=[O:32])[CH2:34][CH2:35]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 54297387[[4-[(7-Chloro-4-quinolinyl)amino]phenyl]sulfonyl]piperazine

Product 1

HCID 213148831-[(4-Chlorophenyl)sulfonyl]-4-[[4-[[7-chloro-4-quinolinyl]amino]phenyl]sulfonyl]-piperazine

Procedure

In the manner given in Example 13 but using 4-chlorophenylsulfonyl chloride in place of sulfamoyl chloride, and [[4-[(7-chloro-4-quinolinyl)amino]-phenyl]sulfonyl]piperazine, 1-[(4-chlorophenyl)sulfonyl]-4-[[4-[[7-chloro-4-quinolinyl]amino]phenyl]sulfonyl]-piperazine is obtained.

Sources & evidence

ORD record
ord-209d54f120164901845cd9fcef7ff201
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Reaction notes

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