Thiophosgene → 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile

Participants

Reaction Steps

The title compound was prepared according to General Method 6. Thiophosgene (10 g, 87.71 mmol) was dissolved in water and stirred at RT for 10 minutes. 4-Amino-2-trifluoromethyl-benzonitrile was added portion wise at RT. The reaction mixture was stirred at RT for 2 h. The product was extracted with dichloromethane, organic layer was washed with water and brine, dried over sodium sulphate and evaporated to obtain 12 g of 4-Isothiocyanato-2-trifluoromethyl-benzonitrile.

Provenance & Evidence