Methyl iodide → HCID 66732501, compound

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared according to General Method 5. A mixture of 2-(3-fluoro-4-(methoxymethyl)phenylamino)-2-methylpropanoic acid (1 g, 4.1 mmol), anhydrous K2CO3 (0.858 g, 6.2 mmol) and methyliodide (0.880 g, 6.2 mmol) was stirred at 60° C. for 3 h. The reaction mixture was diluted with water and extracted with ethyl acetate (20 mL×3), organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain crude product that was purified by silica gel chromatography (eluant 30% ethyl acetate-hexane) to obtain methyl 2-(3-fluoro-4-(methoxymethyl)phenylamino)-2-methylpropanoate.

Provenance & Evidence