4-Bromo-2-propylbenzene-1-sulfonyl chloride → 1-[(2-Propyl-4-bromophenyl)sulfonyl]-4-[[4-[[7-chloro-4-quinolinyl]amino]phenyl]sulfonyl]-piperazine
Reaction equation
[CH2:1]([C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[CH:6][C:5]=1[S:11](Cl)(=[O:13])=[O:12])[CH2:2][CH3:3].[Cl:15][C:16]1[CH:25]=[C:24]2[C:19]([C:20]([NH:26][C:27]3[CH:32]=[CH:31][C:30]([S:33]([N:36]4[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]4)(=[O:35])=[O:34])=[CH:29][CH:28]=3)=[CH:21][CH:22]=[N:23]2)=[CH:18][CH:17]=1>>[CH2:1]([C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[CH:6][C:5]=1[S:11]([N:39]1[CH2:40][CH2:41][N:36]([S:33]([C:30]2[CH:31]=[CH:32][C:27]([NH:26][C:20]3[C:19]4[C:24](=[CH:25][C:16]([Cl:15])=[CH:17][CH:18]=4)[N:23]=[CH:22][CH:21]=3)=[CH:28][CH:29]=2)(=[O:34])=[O:35])[CH2:37][CH2:38]1)(=[O:13])=[O:12])[CH2:2][CH3:3]Participants
3
Procedure
In the manner given in Example 13 but using 2-propyl-4-bromophenylsulfonyl chloride in place of sulfamoyl chloride and [[4-[(7-chloro-4-quinolinyl)amino]phenyl]sulfonyl]piperazine in place of [[4-[(7-trifluoromethyl-4-quinolinyl]amino]sulfonyl] -piperazine, 1-[(2-propyl-4-bromophenyl)sulfonyl]-4 -[[4-[[7-chloro-4-quinolinyl]amino]phenyl]sulfonyl]-piperazine is obtained.
Sources & evidence
- ORD record
- ord-32d4ceb61a5c4cc8b7e6ee797f01a97a
- Source dataset
- uspto-grants-1979_06
- Patent number
- US04159331
Reaction notes
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